Florence Foster Jenkins (Meryl Streep) is a New York City heiress and socialite who founded the Verdi Club to celebrate a passionate love for opera and music. As it is 1944 and the U.S. is in the midst of World War II, Florence is of the opinion that "music matters more than ever." St. Clair Bayfield (Hugh Grant), a British Shakespearean actor, is her husband and manager. Despite being married, Florence and Bayfield live in separate residences. She lives in a grand hotel suite while he resides in an apartment in the city with his secret mistress, Kathleen Weatherley (Rebecca Ferguson). Florence suffers from a long-term case of syphilis, which she contracted from her first husband. The illness has caused her to have various health problems for which she takes medication, including mercury and arsenic, that have toxic side effects. Due to the fear of passing the disease on to Bayfield, she remains abstinent from all sexual intercourse in her marriage, and Bayfield fulfills his sexual urges with Kathleen.