Four years after the death of Damon Macready and defeating Frank D'Amico, Dave Lizewski, bored after having retired from fighting crime as Kick-Ass, begins training with Hit-Girl (Mindy Macready) to become a real hero. Following the death of his father, Chris D'Amico accidentally kills his own mother by kicking her tanning bed, causing it to short-circuit. Now in control of his father's criminal empire, Chris decides to become a supervillain named The Motherfucker, adapting a BDSM suit for his costume, and assembles a gang of supervillains called the Toxic Mega Cunts with his aide Javier and gains a cult following on Twitter, swearing vengeance on Kick-Ass. The other leading members of the Toxic Mega Cunts include African-American UFC fighter Black Death, short stature mob enforcer The Tumor, ex-Triad gang member Genghis Carnage, and the only woman on the team, former Russian bodyguard Mother Russia.