Tom Craig (John Wayne), a pharmacist, arrives in Sacramento and gets into trouble with Britt Dawson (Albert Dekker) for carrying Lacey Miller (Binnie Barnes) across a mud puddle. Tom teams up with Kegs (Edgar Kennedy) and they are thrown off the river boat by Britt’s henchmen. Tom strikes a deal with Lacey to sell his pharmaceuticals in her store. Ellen Sanford (Helen Parrish) and Tom begin a romance. Tom and Kegs organize the settlers to stop Dawson’s land-grabbing gang. Tom proposes to Ellen as she leaves for San Francisco. Helga (Patsy Kelly), Lacey's lady's maid, gun in hand, marches Kegs off to get married. Whitey (Emmett Lynn), the town drunk, drinks Tom’s elixir tonic, which Dawson has poisoned, and dies in Tom’s store. The townspeople take Tom out to hang him, but he is saved when gold is discovered. Dawson shoots up Tom’s store, they fight, and Tom ends up in jail.