Lost in America follows the journey of formerly homeless director, Rotimi Rainwater, as he tries to accept and come to terms with his experience of being a homeless youth. He and his film crew travel the country interviewing homeless youth, organizations aimed to help them, and politicians to gain a better understanding of the issue of youth homelessness. The film looks at the challenges faced by homeless youth such as sex trafficking, the failure of the foster care system and the lack of acceptance of LGBTQ kids.