Three years after the events of the first film, veterinarian Dr. John Dolittle's (Eddie Murphy) ability to talk to animals has made him famous, and he travels the world performing his skills. Returning home from France, he gives his daughter Maya (Kyla Pratt) a chameleon named Pepito (voice of Jacob Vargas), and punishes his other daughter Charisse (Raven-Symoné) for doing poorly in school, confiscating her phone for a week. Charisse's boyfriend Eric (Lil Zane) joins the family for Charisse's 16th birthday party, where a possum (voice of Isaac Hayes) and a raccoon, Joey (voice of Michael Rapaport), tell John that their boss, the Godbeaver (Godfather of the rodent mafia), wants to see him. John meets the Godbeaver (voice of Richard C. Sarafian) and agrees to save the forest from being cut down by mating an endangered female Pacific western bear with a male.