In San Francisco, pharmaceutical chemist William Rodman is testing the viral-based drug ALZ-112 on chimpanzees at the biotech company Gen-Sys to find a cure for Alzheimer's disease. ALZ-112 is given to a chimpanzee named Bright Eyes, greatly increasing her intelligence. However, during Will's presentation for the drug, Bright Eyes is forced from her cage, goes on a rampage, and is shot to death. Will's boss Steven Jacobs terminates the project and has the chimpanzees euthanized. However, Will's assistant Robert Franklin reveals that the reason for Bright Eyes' rampage was that she had recently given birth to an infant chimpanzee. Will reluctantly takes in the chimpanzee, eventually giving him the name Caesar. Discovering that Caesar has inherited his mother's intelligence through being exposed to ALZ-112 before birth, Will decides to raise him. Three years pass, Caesar becomes highly intelligent and can play games, draw pictures, and communicate with Will through sign language. Will introduces Caesar to the redwood forest at Muir Woods National Monument so he can roam. Meanwhile, Will treats his father, Charles, with ALZ-112, which seems to restore his cognitive ability.