Jasmine Francis (Cate Blanchett) disembarks in San Francisco after a flight from New York City. She takes a taxi to her sister Ginger's (Sally Hawkins) apartment, where Ginger is dismayed to learn that Jasmine traveled first class despite claiming to be broke. Jasmine has recently suffered a nervous breakdown and, having incurred heavy debts, has been forced to seek refuge with her sister.
A series of flashbacks reveal that Jasmine's husband, money manager Hal Francis (Alec Baldwin), was arrested for defrauding his clients. Ginger and her husband, Augie (Andrew Dice Clay), were among Hal's victims; he swindled them out of $200,000 of lottery winnings that Augie had wanted to start a business with, and their marriage fell apart. Hal committed suicide in prison after being publicly disgraced. Jasmine's step-son Danny (Alden Ehrenreich) dropped out of Harvard and cut himself off completely from Jasmine, believing her to be complicit in Hal's crimes. After Hal's death, Jasmine began drinking heavily and abusing anti-anxiety medication. She also developed a habit of talking to herself about her past.