San Francisco police officer Frank Conner is in a frantic search for a compatible bone marrow donor for his leukemia-stricken son, Matt. In desperation, he breaks into FBI headquarters and finds a perfect match. Unfortunately, it is Peter McCabe, a sociopath who is serving life in prison for several murders. During his time in prison, the brutal, cunning McCabe has attempted escape and killed several guards and fellow prisoners, and must be kept in multiple restraints when out of his isolation cell.