After eight months of treatment in a mental health facility for bipolar disorder, Patrizio "Pat" Solitano, Jr. (Bradley Cooper) is released into the care of his father Patrizio, Sr. (Robert De Niro) and mother Dolores (Jacki Weaver). His main focus is to reconcile with his ex wife, Nikki (Brea Bee). She has moved away and obtained a restraining order against him after Pat had found her in the shower with another man and nearly beat him to death. During his time in the clinic Pat befriends Danny McDaniels (Chris Tucker), an easygoing man who is embroiled in a legal dispute with the clinic on whether or not he is eligible to leave. Pat's therapist, Dr. Patel (Anupam Kher), does his best to convince him to keep taking his medication, as a repeat of his violent outbursts might send him back to the clinic. But Pat tells him that he has a new outlook on life: he attempts to see the good, or silver linings, in all that he experiences.