Alice wakes up in a mansion. Wandering through its halls, she is forced to escape several security traps. However, she is eventually killed by a bouncing mine hidden in the floor. Her body is dumped into a pit filled with dozens of Alice clones, which is later revealed to be all a part of Project Alice.
Despite the Umbrella Corporation's attempts to cover up the contamination of the Hive, the T-virus' spread to the surface, and the nuclear bombing of Raccoon City, the T-virus has spread around the world; affecting humans, animals, and the environment. The real Alice wanders the wastelands that was once the Southwestern U.S., discovering information about an uninfected area in Alaska. She also realizes that she has developed telekinetic abilities due to the experiments performed on her.