In rural Texas, go-go dancer Cherry Darling runs into her mysterious ex-boyfriend El Wray at the Bone Shack, a restaurant owned by brothers J.T. and Sheriff Hague. Meanwhile, the demented Lt. Muldoon and his men make a transaction with chemical engineer Abby for mass quantities of DC2, a deadly biochemical agent. When Muldoon learns that Abby has an extra supply, he attempts to take Abby hostage, causing him to release the gas into the air, mutating most of the town's residents into deformed zombies. The infected townspeople are treated by Dr. William Block and his unhappy, unfaithful, and bisexual anesthesiologist wife, Dakota at a local hospital.