In Kathmandu, Nepal, the sorcerer Kaecilius and his zealots enter the secret compound Kamar-Taj and behead its librarian. They steal a few pages from an ancient, mystical text belonging to the Ancient One, a long-lived sorcerer who has taught every student at Kamar-Taj, including Kaecilius, in the mystic arts. The Ancient One pursues the traitors, but Kaecilius and his followers escape.
In New York City, Stephen Strange, an acclaimed but arrogant neurosurgeon, severely injures his hands in a car accident, leaving him unable to operate. Fellow surgeon and former lover Christine Palmer tries to help him move on, but Strange vainly pursues experimental surgeries to heal his hands, as he is unwilling to do so. Strange eventually learns of Jonathan Pangborn, a paraplegic who mysteriously regained full use of his legs. Pangborn directs Strange to Kamar-Taj, where he is taken in by Mordo, a sorcerer under the Ancient One. The Ancient One demonstrates her power to Strange, revealing the astral plane and other dimensions such as the Mirror Dimension. She eventually agrees to train Strange, despite his arrogance, which reminds her of Kaecilius.
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