That would have been a very different duet.

From Firefly to Castle, these are our picks for the best Nathan Fillion movies and TV shows from the actor's career so far.

Following Anyone But You's trailer release, The Curse's Nathan Fielder and Emma Stone spoofed Glen Powell and Sydney Sweeney.

Actor Nathan Chasing Horse has been accused of sexual assault going back decades and running a cult.

Tom Holland apparently went undercover to learn a new skill for his new movie Uncharted.

Now that the Uncharted movie is finally hitting theaters, Tom Holland's Nathan Drake is getting his first action figure. Check out an exclusive first look at this upcoming figure from Diamond Select Toys.

In celebration of the upcoming Uncharted film, the video game and movie versions of Nathan Drake and Chloe Frazer will be arriving as Outfits in Fortnite on February 17.

Original Nathan Drake actor Nolan North will narrate the upcoming Uncharted movie novelization, voicing every character, including Drake and Sully.

The hardest part of playing Nathan Drake in Uncharted may not be what you think.

A new Uncharted trailer has been released and has not only given us much more of Tom Holland's Nathan Drake and Mark Wahlberg's Sully in action, but also unveils the long-awaited arrival of Sully's mustache.

Uncharted voice actor Nolan North has good things to say about the new Uncharted movie trailer.

In an Instagram post, Nathan Fillion shared his review of Free Guy and noted how much he appreciated Ryan Reynold's work in the blockbuster.

The Suicide Squad killed off a ton of characters... or did it?

James Gunn showed some well-deserved love to his frequent collaborators.

What would happen if all of Nathan Fillion's characters from James Gunn movies were in a Suicide Squad? Fillion knows the answer.

The Suicide Squad actor was once attached to play Nathan Drake in the video game adaptation.

Nolan North shared his thoughts on Tom Holland's upcoming turn as Nathan Drake.

Behold the debut of Nathan Fillion's T.D.K.!

Nathan Fillion plays a lot of serious characters, but he had a lot of fun with James Gunn on The Suicide Squad.

With fans now having had their first look at Tom Holland as Nathan Drake in the long-awaited Uncharted movie, let's look back at other actors who have played iconic video game characters in live-action adaptations.