NSA Agent Augustus Gibbons attempts to recruit footballer Neymar for the Triple-X (XXX) program when a satellite crashes, apparently killing them both. Shortly afterwards, a team of four skilled individuals led by Xiang infiltrate a highly guarded CIA office in New York City and retrieve "Pandora's Box", a device which is capable of controlling satellites to crash at specific locations as warheads. CIA Agent Jane Mark tracks down former xXx operative Xander Cage, who faked his death and has been living in self-imposed exile in the Dominican Republic, and convinces him to return to active service to retrieve the device.