Bio-chemical expert Dr. Vladimir Nekhorvich sends a message to the IMF for Ethan Hunt, an old friend of his. He warns that his employer at Biocyte Pharmaceuticals forced him to develop a biological weapon to profit from the cure. He arranges to meet with Ethan to deliver the Chimera virus, and its remedy, Bellerophon. With Ethan on holiday, the IMF sends agent Sean Ambrose disguised as Ethan to meet Nekhorvich on a passenger plane. Ambrose goes rogue, killing Nekhorvich and stealing Bellerophon, destroying the aircraft to cover their escape.